Praveen Patidar, PhD
Postdoctoral Research, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, 2012-16
Ph.D. (Biochemistry), New Mexico State University, Las Cruces, 2007-12
M.S. (Life Sciences), Devi Ahilya University, Indore (India) 2003-05
B.S. (Biology/Chemistry), Holkar Science College, Indore (India) 1999-02
Preserving the structural and functional integrity of genetic information is critical for all organisms. DNA is susceptible to various kinds of damage from exposure to endogenous (e.g., reactive oxygen species) and exogenous factors (e.g., radiation). All the organisms have evolved intricate mechanisms involving numerous DNA repair proteins to detect and repair multitude of DNA lesions. Mutations in genes encoding DNA repair proteins lead to genomic instability that is a hallmark of several debilitating diseases including cancer. Complex processes of DNA repair are regulated by interplay of protein-protein/DNA-protein interactions and are required for preserving genomic integrity and avoiding carcinogenesis. Identifying, characterizing and understanding biological significance of such interactions are essential steps for developing potential anti-cancer therapy.
The Patidar lab is broadly interested in understanding the mammalian DNA damage and repair response with emphasis on delineating the molecular functions of novel DNA repair proteins, and seek translational research avenues to utilize these findings. The lab is also interested in developing anti-cancer drugs that create DNA damage and trigger cell death exclusively in cancer cells. Interdisciplinary approaches including protein biochemistry, cell and molecular biology, cancer biology, genomics, and proteomics are routinely employed to drive current research projects.
Currently recruiting M.S. and Ph.D. students. Interested students are encouraged to email their CV and a brief statement of interest.
Patidar P.L., Motea E.A., Fattah F.J., Zhou, Y., Morales J.C., Xie, Y., Garner, H.R., and Boothman D.A. “The Kub5-Hera/RPRD1B interactome: A novel role in preserving genetic stability by regulating DNA mismatch repair” (2016), Nucleic Acids Res., 44(4),1718-31.
Morales J.C., Richard P., Patidar P.L., Motea E.A., Dang T.T., Manley J.L. and Boothman D.A. “XRN2 links transcription termination to DNA damage and replication stress” (2016), PLoS Genet. 12(7):e1006107.
Morales J.C., Motea E.A., Patidar P.L. *, Fattah F.J., Ilcheva M., Burma S., Story M.D. and Boothman D.A., “RNA transcription termination factors and persistent R-loops: potential carcinogenic determinants after high or low LET IR”, THREE (The Health Risks of Extraterrestrial Environment, http://three.jsc.nasa.gov/#section=encyclopedia), 2015, * Equal first author contribution.
Morales J.C., Richard P., Rommel A., Fattah F.J., Motea E.A., Patidar P.L., Xiao L., Leskov K., Wu S., Hittelman W.N., Chiang C., Manley J. L. and Boothman D. A. “Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair”, Nucleic Acids Res., (2014) 42(8), 4996-5006.
Reyes, E.D., Patidar, P.L., Uranga, L.A., Bortoletto, A.S., and Lusetti, S.L. “RecN is a Cohesin-like Protein that Stimulates Intermolecular DNA Interactions in-vitro”, J. Biol. Chem., (2010) 285, 16521-9.
“Kub5/Hera as a determinant of sensitivity to DNA damage”, Boothman D.A., Motea E. A., Patidar P. L. and Morales J. C., U.S. Patent Application No. 62/132,985.
“XRN2 as a determinant of sensitivity to DNA damage”, Boothman D.A., Motea E. A., Morales J. C. and Patidar P. L., U.S. Provisional Patent Application No. 62/340,782.