Dr. Anthony W.G. Burgett will present the Chemistry Department seminar. Dr. Burgett is an associate professor in the Department of Pharmaceutical Sciences, College of Pharmacy, and a member of the Stephenson Cancer Center at the University of Oklahoma Health Sciences Center.
His talk is "Novel Antiviral and Precision Anticancer Therapeutic Development Through Targeting the Oxysterol-binding Proteins (OSBP/ORPs)."
Zoom ID: 991 4324 9255
Our research program seeks to discover the cellular mechanisms of action through which novel bioactive compounds affect biological systems, and then to apply these research discoveries to unlock new understandings in cellular biology and to launch new approaches in the therapeutic intervention of human disease. Our interdisciplinary research combines cellular biology, protein biochemistry, and bioanalysis built on the foundational capability to make and modify complex molecular structures, especially natural products, through organic synthesis. The oxysterol-binding protein (OSBP/ORP) family of human proteins are important mediators of lipid biology, and specific OSBP/ORP family members execute essential functions in cancer proliferation and pathogenic viral infection. The OSBP/ORPs are the cellular targets of a class of structurally-complex natural product compounds. Our current research program uses these natural product compounds as chemical probes to define the OSBP/ORP cellular functions and as starting points for the synthesis of potential lead therapeutic compounds targeting OSBP/ORP family members. Through our organic synthesis research program, we are developing novel routes to produce and identify new OSBP/ORP-targeting analogs as potential lead compounds for antiviral and anti-cancer therapeutic development.